Researchers found that those with genetic signals tied to earlier sexual activity were more prone to aging-related health issues — including frailty and poorer longevity-related measures.
A team from Shandong University, China, examined whether age at first sexual intercourse was related to several aging factors — including longevity, parental lifespan, frailty and self-rated health.
The findings showed that a genetic tendency toward earlier first sexual intercourse was associated with a less favorable multi-dimensional aging profile, shorter longevity-related measures, and higher frailty.
Study first author Kaixian Wang said: "We then explored why this link might exist.
"Among 145 possible mediators, 34 met the criteria for further analysis.
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"Frailty index, miserableness, chronic obstructive pulmonary disease, and attention-deficit/hyperactivity disorder (ADHD) appeared to play especially important roles."
The researchers say their findings, published in the journal Healthcare and Rehabilitation, suggest early life events may leave "long shadows" on later health.
Wang said: "Our findings suggest that the timing of first sexual intercourse may be connected to aging through multiple psychological, behavioral, and disease-related pathways.
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"Nonetheless, our findings do not mean a single behavior determines a person's future health.
"Instead, they highlight how early-life experiences may cluster with mental health challenges, chronic disease risks, and functional decline over time."
Corresponding author Long Sun said: "Prevention and intervention across the life course may help reduce later health disadvantages and promote healthier aging."
He added: "Our findings further affirm the value of early sexual health education and broader support for adolescents who may be at higher risk."
The research team acknowledged that the study was based mainly on genetic data from people of European ancestry, and highlighted the need for further research in other ethnic groups.
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